DNA supercoiling modeling of nucleosome and viral spooling
نویسندگان
چکیده
منابع مشابه
DNA knots and DNA supercoiling.
Type II DNA topoisomerases permit passages of double stranded DNA segments through each other and this is achieved via a complex mechanism involving a transient cleavage of one duplex, a passage of the second duplex through the topoisomerase-spanned cleavage site and finally resealing of the cut duplex. Type II DNA topoisomerases facilitate many DNA transactions requiring manipulation of long D...
متن کاملDNA supercoiling inhibits DNA knotting
Despite the fact that in living cells DNA molecules are long and highly crowded, they are rarely knotted. DNA knotting interferes with the normal functioning of the DNA and, therefore, molecular mechanisms evolved that maintain the knotting and catenation level below that which would be achieved if the DNA segments could pass randomly through each other. Biochemical experiments with torsionally...
متن کاملFluctuations and supercoiling of DNA.
Frequently, DNA in vivo is organized into loops that are partially underwound and consequently form interwound helical supercoils. Methods from polymer statistical mechanics are used to show how the competition between entropy (thermal fluctuations) and elastic energy determines supercoil radius and pitch, in good agreement with recent experiments and simulations. Supercoil reorganization by me...
متن کاملPositive supercoiling affiliated with nucleosome formation repairs non-B DNA structures.
It is demonstrated that positive supercoiling affiliated with nucleosome formation can act as the driving force to repair the G-quadruplex, cruciform as well as a stable non-B DNA structure caused by peptide nucleic acid.
متن کاملSupercoiling in DNA and chromatin☆
Supercoiling is a fundamental property of DNA and chromatin. It is modulated by polymerase and topoisomerase activities and, through regulated constraint, by DNA/chromatin binding proteins. As a non-covalent and elusive topological modification, supercoiling has proved intractable to research despite being a crucial regulator of nuclear structure and function. Recent studies have improved our u...
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ژورنال
عنوان ژورنال: PAMM
سال: 2007
ISSN: 1617-7061,1617-7061
DOI: 10.1002/pamm.200700421